Blue light (470 nm) effectively inhibits bacterial and fungal growth, while not impairing wound healing.
This is one of the most optimized wavelengths for therapy. Optimal cellular absorption of this wavelength’s output ensures maximum effects.
This infrared light emits the most energy per watt compared to other light wavelengths. This band of light is also the most penetrative, delivering energy deeper into the body and designed to coincide exactly with peak absorption.
This is approaching the peak interaction of light with H2O in the body. Although some of the energy is also interacting with the tissue and performing the same function as the 800 to 850nm, the bulk of the energy goes to creating thermal gradients in the H2O that increase circulation and blood flow.
Left image shows the left leg burned following an auto accident.
Right image is the same leg after 4 weeks of using PBM Therapy.
Left image shows the shoulder following surgery.
Right image is the same shoulder after 35 days of using PBM Therapy.
Left image shows the picture of the right foot.
Right image is the same foot after 20 days of using PBM Therapy.
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A multicenter double-blind, placebo-controlled clinical study with 324 patient study documenting patients treated with PhotoBioModulation (PBM) achieved significant improvement from pain associated with medial and lateral epicondylitis. Total relief of the pain with consequently improved functional ability was achieved in 82% of acute and 66%of chronic cases.
View Study
For over forty years, PhotoBioModulation (PBM) has been shown to reduce inflammation and edema, induce analgesia, and promote healing in a range of musculoskeletal pathologies.
View Study
Endothelial cells are vital in wound healing and play a key role in angiogenesis. The direct effect of PhotoBioModulation (PBM) on endothelial cells using lasers in the red spectrum plays a key role in healing endothelial cells.
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This study concludes that the use of red and near-infrared light does help reduce pain and reduce inflammation. It states that one of the most reproducible benefits of red &near-infrared light is its ability to reduce inflammation/edema following injury. This article states that the reduction of edema and reductions in markers of oxidative stress and pro-inflammatory cytokines are well established when using red & near-infrared light.
For over forty years, PhotoBioModulation (PBM) has been shown to reduce inflammation and edema, induce analgesia, and promote healing in a range of musculoskeletal pathologies.
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This study finds that pain and disability associated with knee osteoarthritis is significantly improved when using PhotoBioModulation (PBM).
View StudyThis study showed that the PhotoBioModulation (PBM) group a significant increase of the tissue repair when compared with the control group, with a significant statistical difference (p < 0.013). Conclusions: The use of PBM on chronic wounds in a diabetic foot demonstrated efficacy on the progression of the tissue repair process in a short period.
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This study shows that low level light therapy reduced acute neck pain for up to 22 weeks in chronic neck pain patients.
View StudyThis study concludedthat the biological effects of light therapy promoted a reduction ofinflammatory cells, increased proliferation of fibroblasts, stimulation ofcollagen synthesis, angiogenesis inducement and granulation tissue formation.
View StudyA multicenter double-blind, placebo-controlled clinical study with 324 patient study documenting patients treated with PhotoBioModulation (PBM) achieved significant improvement from pain associated with medial and lateral epicondylitis. Total relief of the pain with consequently improved functional ability was achieved in 82% of acute and 66% of chronic cases. The Use of Low Level
View Study
This study concluded light therapy was safe and effective regarding the shoulder pain reduction and that study showed significant pain reduction scores with those using light therapy.
View Study
PhotoBioModulation (PBM) has been actively used for nearly 40 years, during which time it has been known to reduce pain, inflammation, and edema. It also has the ability to promote healing of wounds, including deep tissues and nerves, and prevent tissue damage through cell death. Much of the landmark research was done by the National Aeronautics and Space Administration (NASA).
View Study
In this article, the authors analyzed the existing literature regarding nonoperative treatment of patellar tendinopathy and provide additional insight on the effectiveness of current modalities including PhotoBioModulation.
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This study documents the PBM test group experienced reduced neck pain, improved function of neck and improved quality of life.
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A double-blind, randomized, placebo-controlled study of 90 patient showing that patients treated with PBM achieved significant improvements in neck pain relief.
View Study
This study shows that light therapy reduced participants’ pain by 70 percent comparedto the placebo for osteoarthritis and rheumatoid arthritis.
View Study
This 69 patient study documented significant improvement and reported reduced pain associated with PBM treatment of patient suffering from heel/plantar fasciitis.
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This study concluded that the biological effects of light therapy promoted a reduction of inflammatory cells, increased proliferation of fibroblasts, stimulation of collagen synthesis, angiogenesis inducement and granulation tissue formation.
View StudyPBM is a promisingand fast expanding physical approach in various medical fields, especially toreduce pain and inflammation and support tissue regeneration.
Roberta T Chow, Mark I Johnson, Rodrigo A B Lopes-Martins, Jan M Bjordal ; Lancet 2009; 374: 1897–908
This report shows that low level light therapy reduced pain in acute neck pain and for up to 22 weeks in patients with chronic neck pain.
Erick M. Marigi, MD, Patrick Buckley, BS, Farzad Razi, BS, Muhammad J. Abbas, BS, Toufic R. Jildeh, MD, Christopher L. Camp, MD, Aaron J. Krych, MD, Kelechi R. Okoroha, MD JBJS March 2022; 10 (3): e21.00168
In this article, we analyze the existing literature regarding nonoperative treatment of patellar tendinopathy and provide additional insight on the effectiveness of current modalities.
Roberta T; Heller, Gillian Z; Barnsley, Les: Pain: September 2006 - Volume 124 - Issue 1 - p 201-210 doi: 10.1016/j.pain.2006.05.018
A double-blind, randomized, placebo-controlled study of 90 patients showing that patients treated with PBM achieved significant improvements in neck pain relief.
David M. Macias, MD, Michael J. Coughlin, MD, Kerry Zang, DPM, Faustin R. Stevens, MD, James R. Jastifer, MD, Jesse F. Doty, MD The Journal of Foot & Ankle Surgery 54 (2015) 768–772
This 69-patient study documented significant improvement and reported reduced pain associated with heel/plantar fasciitis.
Howard B. Cotler, MD, FACS, FAAOS: Curr Orthop Pract. 2015 Jan; 26(1): 72–74. Published online 2014 Dec 31. doi: 10.1097/BCO.0000000000000196
PhotoBioModulation (PBM) has been actively used for nearly 40 years, during which time it has been known to reduce pain, inflammation, and edema. It also has the ability to promote healing of wounds, including deep tissues and nerves, and prevent tissue damage through cell death. Much of the landmark research was done by the National Aeronautics and Space Administration (NASA).
David M. Macias, MD, Michael J. Coughlin, MD, Kerry Zang, DPM, Faustin R. Stevens, MD, James R. Jastifer, MD, Jesse F. Doty, MD The Journal of Foot & Ankle Surgery 54 (2015) 768–772
This study was designed to determine whether addition of PBM to physiotherapy (PT) for AKP in combat soldiers is superior to PT alone. Addition of PBM to PT for treatment of overuse AKP significantly reduces pain in the short term and improves long-term functionality.
Stausholm MB, Naterstad IF, Joensen J, BMJ Open 2019;9:e031142. doi:10.1136/bmjopen-2019-031142
This study finds that pain and disability associated with knee osteoarthritis is significantly improved when using PhotoBioModulation (PBM).
Simunovic Z, Trobonjaca T, Trobonjaca Z.; J Clin Laser Med Surg. 1998 Jun;16(3):145-51. doi: 10.1089/clm.1998.16.145. PMID: 9743652.
A multicenter double-blind, placebo-controlled clinical study with 324 patient study documenting patients treated with PhotoBioModulation (PBM) achieved significant improvement from pain associated with medial and lateral epicondylitis. Total relief of the pain with consequently improved functional ability was achieved in 82% of acute and 66% of chronic cases.
Ernesto Cesar Pinto Leal-Junior & Douglas Scott Johnson & Anita Saltmarche & Timothy DemchakLasers Med Sci (2014) 29:1839–1847 DOI 10.1007/s10103-014-1592-6
We conclude that combination of super-pulsed laser, red and infrared LEDs is effective to decrease pain and improve quality of life in patients with knee pain.
Luciana Gonçalves Langella & Heliodora Leão Casalechi & Shaiane Silva Tomazoni & Douglas Scott Johnson & Regiane Albertini5 & Rodney Capp Pallotta6 & Rodrigo Labat Marcos & Paulo de Tarso Camillo de Carvalho & Ernesto Cesar Pinto Leal-JuniorLasers in Medical Science (2018) 33:1933–1940
The results of this study support the hypothesis that Photobiomodulation therapy applied to the surgical incision in the postoperative period reduces acute pain and inflammation in patients after hip arthroplasty. Previous studies using laser therapy and the visual analog scale as a means of evaluation also reported less pain in the post-surgical period, corroborating the results of this study.
Chukuka S Enwemeka, Deborah Williams, Sombiri K Enwemeka, Steve Hollosi, David Yens: Photomed Laser Surg. 2009 Apr;27(2):221-6. doi: 10.1089/pho.2008.2413.
This study finds that Blue Light is used to help address bacteria issues, including MRSA, that may arise post injury or operation.
Anita R. Gross, Stephanie Dziengo, Olga Boers, Charlie H. Goldsmith, Nadine Graham,Lothar Lilge, Stephen Burnie, Roger WhiteThe Open Orthopaedics Journal, 2013, 7, (Suppl 4: M3) 396-419
We found evidence in favor of LLLT for chronic neck pain indicating further research would be warranted with positive outcomes expected.
Cotler HB, Chow RT, Hamblin MR, Carroll J.; MOJ Orthop Rheumatol. 2015;2(5):00068. doi:10.15406/mojor.2015.02.00068
For over forty years, PhotoBioModulation (PBM) has been shown to reduce inflammation and edema, induce analgesia, and promote healing in a range of musculoskeletal pathologies.
Michael R Hamblin HarvardAIMS Biophys. 2017 ; 4(3): 337–361. doi:10.3934/biophy.2017.3.337.
Advances in understanding of PBM mechanisms of action at a molecular and cellular level, have provided a scientific rationale for its use for multiple diseases.
Ron CLIJSEN, Anina BRUNNER, Marco BARBERO, Peter CLARYS, Jan TAEYMANS European Journal of Physical and Rehabilitation Medicine 2017 August;53(4):603-10DOI: 10.23736/S1973-9087.17.04432-X
This meta-analysis investigated the effectiveness of low-level laser therapy (LLLT) on pain in adult patients with musculoskeletal disorders.
Roberta T. Chow, MBBS (Hons), FRACGP, MAppl Scind, Les Barnsley, B Med (Hons), PhD, Grad Dip Epi, FRACP, FAFRM [RACP] AustraliaLasers in Surgery and Medicine 37:46–52 (2005)
A search was undertaken under taken from date of inception until February 2004 for randomized controlled trials of LLLT for neck pain. A comprehensive list of search terms was applied and explicit inclusion criteria were developed a priori. Twenty studies were identified, five of which met the inclusion criteria. LLLT with infrared wavelengths appears to be efficacious for the treatment of neck pain with limited evidence being provided from the reviewed trials.
João Pedro Scaldaferri Martins, Carlos José de Lima, Adriana Barrinha Fernandea, Leandro Procópio Alves, Osmar Pinto Neto, Antonio Balbin VillaverdeLasers in Medical Science (2022) 37:3155–3167https://doi.org/10.1007/s10103-022-03584-2
The quality of life, pain intensity relief, shoulder range of motion extension, and muscle strength force increase are enhanced by adding infrared and red LED irradiation to ultrasound for patients suffering from rotator cuff tendinopathy. The infrared LED irradiation combined with therapeutic ultrasound is a more promising therapy for clinical practice.
Sturla Haslerud, Liv Heide Magnussen, Jon Joensen, Rodrigo Alvaro Brandao Lopes-Martins & Jan Magnus BjordalPhysiother. Res. Int. 20 (2015) 108–125 © 2014 John Wiley & Sons, Ltd.
The systematic review and meta-analysis suggests that LLLT is a safe and effective treatment alternative for painful shoulder tendons. The clinical benefit does not seem to be limited to LLLT when used as monotherapy. On the contrary, LLLT seems to induce additive effects in terms of reduced pain and a more rapid improvement, even when used as an adjunct to the gold standard of exercise or physiotherapy treatment regimens.
Ho Jang, M.S., and Hyunju Lee, Ph.D.Photomedicine and Laser Surgery, Volume 30, Number 8, 2012, DOI: 10.1089/pho.2012.3240
In this systematic review, we investigate the clinical effectiveness of low-level laser therapy (LLLT) on joint pain. Obtaining pain relief from LLLT might be a good alternative to the use of NSAIDs, particularly for elderly people, because laser therapy has no reported side effects.
Yen-Po Lin, MD, Ying-Hao Su, MD, Shih-Fang Chin, RN, Yu-Ching Chou, PhD, Wei-Tso Chia, MD, PhDa Medicine®
This study revealed that LED therapy could be an effective alternative treatment for NSCLBP by reducing pain and fatigue and improving fear avoidance beliefs, function, and quality of life.
MARGARETA. NAESER, Ph.D., Lic.Ac.Photomedicine and Laser Surgery Volume 24, Number 2, 2006
With an average success rate of 84% (SD, 8.9) across the five positive photoradiation studies (171 hands treated, real laser), photoradiation is a promising new, conservative treatment for CTS in the earlier stages, before irreversible damage has occurred in the median nerve.
Ishaq Ahmed , Mohammad Ali Mohseni Bandpei , Syed Amir Gilani ,Ashfaq Ahmad , and Faryal Zaidi Journal of Healthcare EngineeringVolume 2022, Article ID 6437523, 11 pageshttps://doi.org/10.1155/2022/6437523
PBM has proven to be an efficient adjunct therapy to conventional physical therapy for discogenic lumbar radiculopathy. The results of the Wilcoxon signed-rank test score as well as Mann-Whitney U test indicated a statistically significant difference in values.
ZeYu Huang, Jun Ma, Jing Chen, Bin Shen1, FuXing Pei and Virginia Byers KrausArthritis Research & Therapy (2015) 17:360DOI 10.1186/s13075-015-0882-0
The WMD in visual analog scale (VAS) pain outcome score after treatment was significantly lower in the PBM group compared with placebo. Our findings indicate that PBM is an effective method for relieving pain in NSCLBP patients.
Joelita de Alencar Fonseca Santos, MD, Mariana Barbosa Dias Campelo, MD, Rauirys Alencar de Oliveira, PhD, Renata Amadei Nicolau, PhD, Veroˆ nica Elis Arau´ jo Rezende, MD, and Emilia Angela Loschiavo Arisawa, PhDPhotomedicine and Laser Surgery Volume 36, Number 6, 2018 DOI: 10.1089/pho.2018.4455
To analyze the efficacy of the therapeutic use of Low-Level Laser Therapy (LLLT) on the tissue repair process of chronic wounds in patients with diabetic feet.
Shirin Farivar, Talieh Malekshahabi , Reza Shiari Journal of Lasers in Medical Sciences
This review will cover some of the proposed cellular mechanisms responsible for the effect of visible light on mammalian cells, including cytochrome c oxidase (with absorption peaks in the Near Infrared (NIR)).
Sabrina Rohringer, Wolfgang Holnthoner, Sidrah Chaudary, Paul Slezak, Eleni Priglinger, Martin Strassl, Karoline Pill, Severin Mühleder,, Heinz Redl & Peter DungelSCientifiC REpOrTS | 7: 10700 | DOI:10.1038/s41598-017-11061-y
Low level light therapy (LLLT) is a promising and fast expanding physical approach in various medical fields, especially to reduce pain and inflammation and support tissue regeneration20. Numerous in vivo studies indicated a positive effect of LLLT by laser light on wound healing associated with enhanced angiogenesis.
Hoon Chung, Tianhong Dai, Sulbha K. Sharma, Ying-Ying Huang, James D.Carroll, and Michael R. HamblinAnn Biomed Eng. 2012 February ; 40(2): 516–533. doi:10.1007/s10439-011-0454-7.
Advances in design and manufacturing of LLLT devices in the years to come will continue to widen the acceptability and increase adoption of the therapy among the medical profession, physical therapists and the general public. While the body of evidence for LLLT and its mechanisms is still weighted in favor of lasers and directly comparative studies are scarce, ongoing work using non-laser irradiation sources is encouraging and provides support for growth in the manufacture and marketing of affordable home-use LED devices. The almost complete lack of reports of side effects or adverse events associated with LLLT gives security for issues of safety that will be required.
Homa Bahrami, PhD, Alireza Moharrami, MD, Peyman Mirghaderi,Seyed Mohammad Javad Mortazavi, MD IranArthroplasty Today 19 (2023) 1e9
In the early stages of recovery after total knee arthroplasty, LLLT and Bioptron light therapy could be helpful to control immediate and acute knee pain and swelling, reduce the need for opioids, improve ROM and functional scores, and improve recovery.
Maria Emília de Abreu Chaves, Angélica Rodrigues de Araújo, André Costa Cruz Piancastelli, Marcos PinottiAn Bras Dermatol. 2014;89(4):616-23.
The reviewed studies show that phototherapy, either by LASER or LED, is an effective therapeutic modality to promote healing of skin wounds.
Gerald Ross, DDSPhotobiomodulation, Photomedicine, and Laser SurgeryVolume 37, Number 11, 2019 DOI: 10.1089/photob.2019.4711
In their review Photobiomodulation: Implications for Anesthesia and Pain Relief concluded that her review provides strong evidence neuroscience identifying inhibition of neural function as a mechanism for the clinical application of PBM in pain and anesthesia.
